Long‐Term Testosterone Treatment in Elderly Men with Hypogonadism and Erectile Dysfunction Reduces Obesity Parameters and Improves Metabolic Syndrome and Health‐Related Quality of Life

Long‐Term Testosterone Treatment in Elderly Men with Hypogonadism and Erectile Dysfunction Reduces Obesity Parameters and Improves Metabolic Syndrome and Health‐Related Quality of Life

Thus, we speculated the effectiveness of T undecanoate application in maintaining androgen levels necessary to induce BPH. This is the first study, to the best of our knowledge, on application of long-acting potential of T undecanoate to induce BPH instead to treat gonadal function by considering optimal dosage and dosing cycle. Rats in the administration group were castrated and administered a single subcutaneous injection of T undecanoate or T propionate at concentrations of 125, 250, 500, 750, or 1000 mg/kg body weight (b.wt) after their operation. The testosterone concentration was decided higher than 125 mg/kg b.wt, which is referred to previous study that report the higher level of serum testosterone compared to normal control after administration of T undecanoate [28]. Both control groups and 1000mg/kg b.wt group consisted of 5 rats, other group consisted of 6 rats at the beginning of the experiment, total 69 rats were used. Nevertheless, it must be concluded that so far no clear relationship between LUTS and testosterone could be demonstrated.

  • Furthermore, because TU requires only four injections per year compared with 26 injections per year with TE, there
    is a greater compliance rate in patients treated with TU.
  • Given that there is currently no global consensus on the medical approach to T deficiency, and that existing T replacement treatments are surrounded by conflicting efficacy and safety research and clinical reports, it comes as no surprise that alternative approaches to rectifying low T levels are increasing in number.
  • In fact, some researchers argue that declining testosterone may not be attributable to aging in itself, but to the fact that older men tend to gain weight more and develop more diseases.
  • “Which comes first, the hen or the egg?” says Dr. Farid Saad, the director of global medical affairs for andrology at Bayer HealthCare Pharmaceuticals in Berlin, which markets a testosterone injection called Nebido.
  • Starting in the fourth or fifth decade of life, total T concentrations begin to decline progressively by approximately 1 % per year from an average between 270 and 1070 ng/dL, while bioavailable T is approximately 110–575 ng/dL in men who are 18–69 years old.

Its products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. Bayer is committed to driving sustainable development and generating a positive impact with its businesses. At the same time, the Group aims to increase its earning power and create value through innovation and growth. In fiscal 2021, the Group employed around 100,000 people and had sales of 44.1 billion euros. Nebido for the treatment of male hypogonadism (testosterone deficiency) is available in over 80 countries since 2004.

Elevated Endogenous Testosterone Levels are not Associated With Significant Clinical Morbidity

Bayer Schering Pharma AG is recognized for providing the study medication free of charge and an independent grant. For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more. Enjoy extended coverage for the most complete market view with BioWorld, BioWorld MedTech, and BioWorld Asia in a single, easy to access subscription. If you are a man with low testosterone and are considering Nebido therapy, it is important to make an informed decision.

  • Researchers were eventually able to synthesize testosterone, and drugmakers capitalized on the discovery by using it to develop medical treatments.
  • Furthermore, even those conditions are multi-factorial why an association with the protein markers cannot be considered as a proof of an androgen-dependent effect.
  • Carnitine is a key metabolite in energy metabolism in most mammals, where it supports energy metabolism by transporting long-chain fatty acids into mitochondria for energy production.

It could well be that the detrimental effects of testosterone deficiency and the benefits of testosterone treatment are indirect. The following sections will discuss the various elements of the urodynamic system on which T impacts. In light of recent guidance [85] on the restriction of exogenous T administration warranted by observational studies indicating a potential increased risk of cardiovascular events [86, 87] in hypogonadal and/or aging men, SARMs are https://www.hmarochi.com.br/us-dominates-as-top-rated-steroid-suppliers-for/ promising candidates. Pre-clinical models
looking at SARMs
have shown a positive levatorani/bulbocavenous muscle complex/prostate ratio, demonstrating an improved anabolic/androgenic ratio with limited side effects [88–90]. We found TU significantly improved obesity parameters (body weight, waist circumference, and BMI) and lowered total cholesterol, LDL cholesterol, triglycerides, fasting blood glucose, HbA1c, and blood pressure over the 5‐year study.

Study Design

This study suggests an extended application of testosterone undecanoate for inducing benign prostatic hyperplasia that can improve research reliability considering the half-life of testosterone as well as injection dosage and concentration. Testosterone undecanoate (TU) is available as a relatively long‐acting nonhepatotoxic oral steroid therapy for the treatment of T deficiency. The midchain undecanoate fatty acid molecule, present at the 17β‐position, enhances solubility in oil and, therefore, TU bypasses the liver by entering the lymphatic system. However, clinical regimens have been shown to be most effective when provided as an intramuscular injection [20].

Two hundred sixty‐one patients (mean age 59.5 ± 8.4 years) diagnosed with LOH and ED were treated with long‐acting TU in a prospective, observational, and longitudinal registry study. Men received intramuscular injections of 1,000 mg TU at day 1, at week 6, and every 3 months thereafter. Fifteen ovariectomized FtM subjects from an outpatient clinic were divided into three groups to receive TU 1,000 mg alone or in combination with oral administration of letrozole (L) 2.5 mg/die or dutasteride (D) 0.5 mg/die for a period of 54 weeks. This news release contains forward-looking statements based on current assumptions and forecasts made by Bayer Group management.

Toward the end of the 19th century, Charles-Idouard Brown-Siquard, a French physiologist, began injecting himself with “juice” extracted from crushed dog or guinea-pig testicles, as reported in The Lancet in 1889. Although he contended that the injections were rejuvenating, subsequent researchers came to believe that the placebo effect was at work. Drugmakers spent $107 million in 2012 to advertise the top brand-name testosterone drugs in the United States, according to Kantar Media. That amount doesn’t include marketing known as unbranded campaigns, which raise awareness of low T itself. From 2000 to 2011, there was “a major and progressive increase” in testosterone use in 37 countries, according to a recent study published in the Medical Journal of Australia. One afternoon a few months ago, a 45-year-old sales representative named Mike called “The Dr. Harry Fisch Show,” a men’s health program on Sirius XM Radio, where no male medical or sexual issue goes unexplored.

“Which comes first, the hen or the egg?” says Dr. Farid Saad, the director of global medical affairs for andrology at Bayer HealthCare Pharmaceuticals in Berlin, which markets a testosterone injection called Nebido. Researchers were eventually able to synthesize testosterone, and drugmakers capitalized on the discovery by using it to develop medical treatments. He added that the company continues to finance research into the long-term effects of testosterone therapy and that its unbranded informational efforts, like the IsItLowT.com site, “follow FDA’s guidance.” Yet some researchers warn that men whose problems are not caused by low testosterone are also taking the drugs, potentially putting them at unneeded risks for side effects.

However, our findings cannot be used as a direct proof of hypogonadism being cause of cardiometabolic disease but the combined parameter MMA may in this context be an important tool in the detection of long-term morbidity, such as bone mineral density and cardiometabolic risk, even before clinical diagnosis. The change in the epithelial thickness of the prostate tissue, a characteristic of BPH, was measured by H&E staining. Compared with the NC group, the CC group showed a significant decrease, up to an unmeasurable level, in the thickness of the prostate tissue (Fig 4A and 4B). In contrast to the promotion of testosterone tests on DriveForFive.com, for instance, the Endocrine Society recommends against screening the general population. For one thing, men’s testosterone levels fluctuate so wildly — depending on time of day, sleep quality, whether they just ate, whether they are taking care of a newborn and even how their favorite sports team is faring — that a single low testosterone reading may not indicate a problem.

A critical analysis of the role of testosterone in erectile function: From pathophysiology to treatment—a systematic review

Those proteins – alone or in combination – are promising as useful parameters in the clinical diagnosis of male hypogonadism and in the prediction of its long-term sequelae, as well as in studying the biology of androgen action. More extensive testing is vital to elucidate their BAA potential, not only in men but also in women and in prepubertal boys. In this study, we have applied an immunoassay for measuring T levels, although some consider liquid chromatography–tandem mass spectrometry (LC–MS/MS) as gold standard in assessment of sex hormone levels.

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